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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIRT2
All Species:
13.33
Human Site:
S226
Identified Species:
24.44
UniProt:
Q8IXJ6
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IXJ6
NP_036369.2
389
43182
S226
P
K
C
E
D
C
Q
S
L
V
K
P
D
I
V
Chimpanzee
Pan troglodytes
XP_001168156
319
35635
F181
F
S
C
M
Q
S
D
F
L
K
V
D
L
L
L
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_855382
347
38546
K209
C
M
Q
S
D
F
L
K
V
D
L
L
I
I
M
Cat
Felis silvestris
Mouse
Mus musculus
Q8VDQ8
389
43238
S226
P
R
C
E
Q
C
Q
S
V
V
K
P
D
I
V
Rat
Rattus norvegicus
Q5RJQ4
350
39301
S212
R
F
F
S
C
M
Q
S
D
F
S
K
V
D
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001017414
412
44719
S240
P
K
C
D
K
C
Q
S
V
V
K
P
D
I
V
Frog
Xenopus laevis
NP_001088636
413
45548
N254
P
K
C
E
K
C
N
N
L
V
K
P
D
I
V
Zebra Danio
Brachydanio rerio
Q7ZVK3
379
42296
S224
P
K
C
D
S
C
G
S
L
V
K
P
D
I
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650880
355
40094
E217
K
R
F
Y
S
S
P
E
E
D
F
Q
D
C
D
Honey Bee
Apis mellifera
XP_393038
355
40940
I217
E
Q
I
F
K
N
V
I
P
K
C
E
E
C
N
Nematode Worm
Caenorhab. elegans
Q21921
607
68747
G292
A
H
C
K
R
C
E
G
V
I
K
P
N
I
V
Sea Urchin
Strong. purpuratus
XP_001195952
400
43895
G223
C
A
K
C
N
E
T
G
V
V
K
P
D
V
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P53686
357
39961
V219
K
H
P
Q
Q
P
L
V
I
V
V
G
T
S
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
82
N.A.
75.8
N.A.
87.6
78.4
N.A.
N.A.
63.3
63.4
63.5
N.A.
43.7
47.5
25.2
47.2
Protein Similarity:
100
82
N.A.
82.2
N.A.
94.5
84.5
N.A.
N.A.
78.4
76
77.8
N.A.
59.6
61.4
39.8
64.7
P-Site Identity:
100
13.3
N.A.
13.3
N.A.
80
13.3
N.A.
N.A.
80
80
80
N.A.
6.6
0
40
33.3
P-Site Similarity:
100
26.6
N.A.
26.6
N.A.
93.3
20
N.A.
N.A.
93.3
86.6
86.6
N.A.
13.3
13.3
73.3
53.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
33.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
52.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
16
0
54
8
8
47
0
0
0
0
8
0
0
16
0
% C
% Asp:
0
0
0
16
16
0
8
0
8
16
0
8
54
8
8
% D
% Glu:
8
0
0
24
0
8
8
8
8
0
0
8
8
0
0
% E
% Phe:
8
8
16
8
0
8
0
8
0
8
8
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
8
16
0
0
0
8
0
0
0
% G
% His:
0
16
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
8
0
0
0
0
8
8
8
0
0
8
54
0
% I
% Lys:
16
31
8
8
24
0
0
8
0
16
54
8
0
0
0
% K
% Leu:
0
0
0
0
0
0
16
0
31
0
8
8
8
8
24
% L
% Met:
0
8
0
8
0
8
0
0
0
0
0
0
0
0
8
% M
% Asn:
0
0
0
0
8
8
8
8
0
0
0
0
8
0
8
% N
% Pro:
39
0
8
0
0
8
8
0
8
0
0
54
0
0
0
% P
% Gln:
0
8
8
8
24
0
31
0
0
0
0
8
0
0
0
% Q
% Arg:
8
16
0
0
8
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
8
0
16
16
16
0
39
0
0
8
0
0
8
0
% S
% Thr:
0
0
0
0
0
0
8
0
0
0
0
0
8
0
0
% T
% Val:
0
0
0
0
0
0
8
8
39
54
16
0
8
8
54
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _